运动和营养素的细胞内作用靶点——线粒体:阿尔茨海默病防治的新思路

Targeting Mitochondria with Exercise and Nutrients:A New Strategy for the Prevention of Alzheimer Disease

阿尔茨海默病(Alzheimer Disease,AD)是一种与年龄相关的神经退行性疾病,目前缺乏有效的防治方法。研究表明,适量的运动和营养素,可以通过改善脑内线粒体的功能,延缓认知功能衰退和阿尔茨海默病的发生和发展。我们将这类靶向于线粒体的营养素或天然产物定义为线粒体营养素。本文从线粒体角度,综述了运动和线粒体营养素对阿尔茨海默病中神经元的作用机制,为阿尔茨海默病的防治提供新的思路。

AAlzheimer disease （AD） is an age-related neurodegeneration disease and there is no effective way of treatment at present. Previous studies reported that moderate exercise and nutrients, which promote brain mitochondrial function, could delay or slow down cognitive decline and the progression of AD. Such nutrients or natural products, which are targeted at mitochondria, are defined as mitochondrial nutrients. The paper summarizes the effects of exercise and mitochondrial nutrients on the neurons in AD in order to provide new strategy for the treatment and prevention of AD.