联合用药在治疗大鼠消化性溃疡中的作用

The function of united medication in treating mouse digital ulcer

采用大鼠乙酸性胃溃疡模型，观察并比较了丙胺太林、土霉素、呋喃唑酮及其组间联合用药即丙胺太林＋土霉素、丙胺太林＋呋喃唑酮及法莫替丁的抗溃疡作用。其溃疡抑制率分别为45．5％、32．1％、50.6％、60.5％、65.4％及59.6％，说明组间联合用药的抗溃疡作用明显优于单药及法莫替丁。体外抑菌实验证明：联合用药对幽门螺杆菌（Hp）的抑制作用也明显优于单药及丽珠得乐。

By using the model of mouse acetic acid - gastric ulcer, the antiulcer function of Propanthe-line, Terramycine, Furazolidone and the intergroup united medication, namely Propantheline plus Terramycine,Propantheline plus Furazolidonc and Ethinylestradiol were observed and compared. The inhibiting rate of ulcerwere 45. 5 %, 32. 1 %, 50. 6 %, 60. 5 %, 65. 4 % and 59. 6 % rcspectively. The results suggested that the an-tiulcer function of the intergroup united medication was muchbetter than single drug and Ethinylestradiol. Theexperiment of bacteria inhibition in vitro indicated that the inhibiting effect of thc united medication on helical-bacter pylori was much better than single drug and Bismuth subcitrate colloidal.