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临床应用口服抗血小板药物与质子泵抑制剂的思考 被引量：6

Combination of antiplatelet drugs and proton pump inhibitors in clinical practice
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摘要 大量循证医学证据证实抗血小板治疗能有效降低风险人群的不良心血管事件。然而，伴随抗血小板新药研发，以及双联甚或三联强效方案的应用，
作者 卢长林 李忠佑 杨跃进
机构地区 首都医科大学附属北京同仁医院心内科 北京大学人民医院心脏中心 中国医学科学院北京协和医学院阜外心血管病医院冠心病中心
出处 《中国心血管杂志》 2013年第6期412-415,共4页 Chinese Journal of Cardiovascular Medicine
关键词 抗血小板药物 质子泵抑制剂 药物相互作用 氯吡格雷 Antiplatelet drugs Proton pump inhibitors Drugs interaction Clopidogrel
分类号 R973 [医药卫生—药品]
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参考文献20

  • 1Abraham NS, Hlatky MA, Antman EM, et al. ACCF/ACG/ AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. Am J Gastroenterol, 2010,105:2533-2549.
  • 2Wiirtz M,Grove EL, Kristcnsen SD, et al. The antiplatelet effectof aspirin is reduced by proton pump inhibitors in patients with coronary artery disease. Heart, 2010,96:368-371.
  • 3Chariot M,Grove EL, Hansen PR, ct al. Proton pump inhibitor use and risk of adverse cardiovascular events in aspirin treated patients with first time myocardial infarction: nationwide propensity score matched study. BMJ, 2011,342 : d2690.
  • 4Gilard M,Arnaud B, Cornily JC, et al. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. J Am Coil Cardiol, 2008,51:256-260.
  • 5Juurlink DN,Gomes T, Ko DT, et al. A population-based study of the drug interaction between proton pump inhibitors and clopidogrel. CMAJ, 2009,180:713-718.
  • 6Ho PM,Maddox TM, Wang L, associated with concomitant use et al. Risk of adverse outcomes of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA, 2009,301 : 937 -944.
  • 7Stockl KM,Le L, Zakharyan A, et al. Risk of rehospitalization for patients using clopidogrel with a proton pump inhibitor. Arch Intern Med, 2010,170:704-710.
  • 8Siner-Matula JM, Jilma B, Schrtir K, et al. Effect of proton pump inhibitors on clinical outcome in patients treated with elopidogrel: asystematic review and meta-analysis. J Thromb Haemost, 2010,8 : 2624-2641.
  • 9Hulot JS,Collet JP, Silvain J, et al. Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19 * 2 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis. J Am Coil Cardiol, 2010,56 : 134-143.
  • 10O'Donoghue ML, Braunwald E, Antman EM, et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. Lancet, 2000,374:989-997.

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中国心血管杂志
2013年 第6期

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