电针治疗功能性消化不良疗效及对血浆CCK、神经肽Y的影响

Efficacy of electro-acupuncture treatment on functional dyspepsia and its effect on plasma CCK,neuropeptide Y

目的:观察电针治疗功能性消化不良(functional dyspepsia,FD)的临床疗效及对血浆胆囊收缩素(CCK)、神经肽Y的影响。方法:100例FD患者分为治疗组和对照组,每组50例,治疗组采用电刺激足三里穴和内关穴,每周5次为1个疗程,共治疗4个疗程;对照组口服雷贝拉唑(10 mg bid)、盐酸依托必利(50 mg tid)治疗共4周,分别于治疗前、治疗结束时、治疗后1月由受试者填写尼平消化不良指数(NDI,Nepean Dyspepsia Index)、消化不良症状积分(FDI,FD Symptom Index),同时检测治疗前后患者血浆CCK、神经肽Y水平。结果:疗程结束时及治疗后1月随访,电针治疗组症状指数NDSI(Nepean Dyspepsia Symptom Index)与FDI积分均明显低于对照组(P<0.05),而生活质量指数NDLQI(Nepean Dyspepsia Life Quality Index)积分均明显高于对照组(P<0.05)。治疗前后2组患者血浆CCK均显著降低(P<0.05),但治疗组更为显著(P<0.05);治疗后,治疗组神经肽Y出现明显的上升(P<0.05),而对照组神经肽Y无明显变化(P>0.05)。结论:对足三里穴和内关穴进行电针治疗,能明显提高功能性消化不良的疗效,提高患者的生活质量,其疗效可能与电针刺激能降低血浆CCK水平、同时提高血浆神经肽Y水平有关。

Objective： To observe the clinical efficacy of electro-acupuncture treatment on functional dyspepsia （functional dyspepsia, FD） and its effect on plasma cholecystokinin hormone （CCK）and neuropeptide Y. Methods： 100 patients with FD were divided into the treatment group and the control group, 50 in each group. In the treatment group, electrical stimulation was used on Zusanli and Neiguan, 0. 5 hours one time, 5 times a week for a course of treatment, a total of four treatment courses. In control group,patients were taken Rabeprazole （10 mg bid） , Itopride hydrochloride （50 mg tid）, a total of four weeks. Patients fill in the NDI （Nepean Dyspepsia Index） and FDI （ FD Symptom Index） before treatment, after treatment and 1 month after treatment respectively. The plasma CCK and neuropeptide Y were also detected simultaneously before and after treatment. Result： The index of NDSI （Nepean Dyspepsia Symptom Index） and FDI were significantly lower in electro-acupuncture treatment group than those in the control group after treatment and 1 month after treatment （ P 〈 0.05 ） , while the quality of life index NDLQI （ Nepean Dyspepsia Life Quality Index） were significantly higher （ P 〈 O. 05 ）. After treatment, the plasma CCK in all patients was significantly lower （ P 〈 0. 05 ）, but the plasma CCK in treatment group was significantly lower than that in the control group （P 〈 0.05 ）; After treatment, the neuropeptide Y significantly increased （P 〈 0.05 ） in treatment group, while no significant change （ P 〉 O. 05 ） in control group. Conclusion： electro-acupuncture treatment on Zusanli and Neiguan can significantly improve the efficacy and improve the quality of life of fimctional dyspepsia patients, its efficacy may be related to the electro-acupuncture stimulation can reduce the level of plasma CCK, while improving plasma neuropeptide Y levels.