格列吡嗪对2型糖尿病病人血清胰岛素样生长因子及其结合蛋白的影响

The effects of glipizide on serum IGF-1, IGF-2, IGFBP-1 and IGFBP-3 In type 2 diabetics

目的探讨格列吡嗪治疗对２型糖尿病病人血清胰岛素样生长因子（ＩＧＦ）及其结合蛋白（ＩＧＦＢＰ）的影响。方法采用病例对照及治疗前后自身对照研究，了解糖尿病病人空腹血清ＩＧＦ－１、ＩＧＦ－２和ＩＧＦＢＰ－１、ＩＧＦＢＰ－３水平及格列吡嗪治疗２周后的改变情况。其中糖尿病组４０例，正常对照组９０例，两组年龄无显著性差异，Ｐ＞０．０５。结果与正常对照组比，糖尿病组治疗前ＩＧＦ－１水平降低（２３４．４１±１４１．７８ｖｓ １８１．７６±１０４．４８ｎｇ／ｍｌＰ＜０．０５），ＩＧＦＢＰ－１水平升高（４７． ６５±３１． ７８ｖｓ ６８． ８２±４３． １８ｎｇ／ｍｌ， Ｐ＜０． ０１），ＩＧＦ－２和 ＩＧＦＢＰ－３改变不明显。格列吡嗪治疗后 ＩＧＦ－Ｉ升高（１８１． ８±１０４．５ ｖｓ ２０９．０±８８．２ ｎｇ／ｍｌ，Ｐ＜０．０５）；ＩＧＦＢＰ－１则明显下降（６８．８２±４３．１８ ｖｓ ４３．７２±３４． ３５ ｎｇ／ｍｌ，ｐ＝０．００１）；ＩＧＦ－Ⅱ，ＩＧＦＢＰ－３无明显变化。结论格列吡嗪治疗可改善２型糖尿病所导致的血清ＩＧＦ－Ｉ和ＩＧＦＢＰ－１水平改变。

Objectives To study the effects of glipizide on the serum IGF-1, IGF-2, IGFBP-1 and IGFBP-3 in patients with type 2 diabetes mellitus. Methods A case-control study and a self-controlled study were Conducted, and fasting serum IGF-1, IGF-2, IGFBP-1 and IGFBP-3 were assayed by IRMA in 90 healthy subjects, and in 40 subjects with type 2 diabetes pre-and post-treated with glipizide. Results Fasting serum levels of IGF-1 were significantly lower in the diabetes group than in the healthy group(234. 41±141. 78 vs 181. 76±104. 48ng/ml P<0. 005),serum levels of IGFBP-1 increased significantly(47. 65±31. 78 vs 68.82±43. 18ng/rnl, P<0. 01) in diabetes group,and the difference of serum IGF-2 and IGFBP-3 between the two groups were not significant. Two weeks after glipizide treated, there were markedly increased IGF-1 concentrations (181. 8±104. 5 vs 209. 0±88. 2ng/ml P<0. 05) and reduced serum IGFBP-1 (68.82±43. 18 vs 43.72±34. 35ng/ml,P<0. 001)in diabetes group, while serum IGF-2 and IGFBP-3 did not change. Conclusion Glipizide treatment could improve the changes of serum IGF-1 and IGFBP-1 in type 2 diabetes mellitus.