糖尿病视网膜病变与血浆中ET、CGRP、TXB_(2)、6-Keto-PGF_(1α)的相关分析

Analysis of the relationship of ET、CGRP、TXB_(2) and 6-Keto-PGF_(1α) in blood plasma with diabetic retinopathy

目的为了探讨血浆内皮素（ＥＴ）、降钙素基因相关肽（ＣＧＲＰ）、血栓素Ｂ２（ＴＸＢ２）、６－酮－前列腺素Ｆ１α（６－Ｋｅｔｏ－ＰＧＦ１α）四种活性物质在糖尿病视网膜病变发生、发展过程中相互作用的动态变化。方法采用放射免疫法测定了４０例２型糖尿病无视网膜病变组，４０例２型糖尿病单纯型视网膜病变组，４０例２型糖尿病增殖型视网膜病变组以及４０例正常对照组血浆中ＥＴ、ＣＧＲＰ、ＴＸＢ２、６－Ｋｅｔｏ－ＰＧＦ１α数值。结果随着糖尿病病程的延长及视网膜受损程度的加重，ＥＴ呈递进增高趋势（Ｐ＜０．０１），ＣＧＲＰ在糖尿病视网膜病变晚期呈下降趋势（Ｐ＜０．０５，Ｐ＜０．０１）。直线回归相关分析表明，ＥＴ／ＣＧＲＰ与ＴＸＢ２／６－Ｋｅｔｏ－ＰＧＦ１α随着糖尿病视网膜病变的加重，相关性越密切（ｒ＝０．４４，Ｐ＜０．０５；ｒ＝０．５９６，Ｐ＜０．０１）。结论四种活性物质在糖尿病视网膜病变的发生发展过程中的相互关系，对于糖尿病的发病机理、病情发展及指导用药有重要的意义。

Objective To study the changes of the four active substances endothelin(ET),calcitonin gene related peptide (CGRP), thromboxane B2 (TXB2) and 6-Keto-prostaglandin F1α (6-Keto-PGF1α) in plasma when they acted on . each other in the formation and development of diabetic retinopathy. Methods Using the method of radio-immunity,the levels of ET,CGRP,TXB2, 6-Keto-PGF,. in plasma were measured in four groups of patients with type 2 diabetes (group 1: 40 cases without retinopathy; group 2: 40 cases with primary retinopathylgroup 3. 40 cases with hyperplasia type of retinopath; group 4: 40 cases normal controls). Results The results showed that ET increased progressively (P<0. o1) with the prolonging of the duration of DM and the worsening of retina damage .CGRP showed a decreasing tendency (P<0.05, P<0.01) in the advanced stage of DM retinopathy. Rectilinear regression analysis showed that the association of ET/CGRP with TXB2/6-Keto-PGF1α became closer with the worsening of deabetic retinopathy (r=0. 44, P<0. 05; r=0. 596, P<0. 01). Conclusion The four active substances acted on each other in the formation and development of diabetic retinopathy. It had a significent meaning in the initial mechanism of DM,in the development of disease and in the direction of medication usage to understand their relationship.