布比卡因+氟哌利多分别与咪唑安定和曲马多组合用于硬膜外术后镇痛的比较

COMPARISON OF BUPIVACAINE AND DROPERIDOL JOINTLY USED WITH MIDAZOLAM OR TRAMADOL FOR EPIDURAL ANALGESIA

目的 :比较布比卡因 +氟哌利多分别与咪唑安定或曲马多组合用于硬膜外术后镇痛的效果及副反应。方法 :将 6 0例腹部及下肢手术的病人随机分为 3组 ,A组用药为布比卡因 130mg +氟哌利多 5mg ;B组用药为布比卡因 130mg +咪唑安定 5mg +氟哌利多 5mg ;C组用药为布比卡因 130mg +曲马多 30 0mg +氟哌利多 5mg。术后观察镇痛效果 (Keel疼痛描述四分法 -VerbalratingVRS)及副反应。结果 :B、C组镇痛效果优于A组 ,B、C组之间无明显差别 ,镇痛期间 3组病人均无呼吸抑制 ,3组病人的恶心呕吐及尿潴留的发生率均很低 ,且相互之间无显著差异。结论 :布比卡因

OBJECTIVE:To compare the efficacy and side effects of bupivacaine and droperidol jointly used with midazolam or tramadol respectively for epidural analgesia. METHOD:60 patients who had accepted abdomen or lower limbs operation were randomly assigned to three groups:Group A:bupivacaine 130 mg+droperidol 5 mg;Group B:bupivacaine 130 mg+midazolam 5 mg+droperidol 5 mg;Group C:bupivacaine 130 mg+tramadol 300 mg+droperidol 5 mg.After operation the degree of pain and side effects were observed.RESULTS:The efficacy of group B,C were better than group A and the efficacy of group B,C were similar.In these three groups there was no respiratory arrest.Incidences of nousea,vomitting and retenion of urine were very low,and there was no much difference among them.CONCLUSION: The effects of combined analgesia of bupivacaine,droperidol,midazolam or tramadol are very well and there are very few side effects.