实验性心包炎心钠素与组织病理学变化的相关研究

The Study of the Relations Between Atnal Natriurelic Peptide Myocurdial Enzymes and Histopatology in Experimental Pericarditis

目的 :探讨心包炎心钠素和组织病理学变化及相关性 ,为临床心包炎进展期的判定提供理论和实验依据。方法 :试验组家兔 13只 ,心包腔内注入 30 %尿素 ;对照组 11只 ,注入等量生理盐水。观察血浆和心肌心钠素 (ANP)的变化 ,心包组织病理学变化。结果 :血浆ANP术后 1天开始上升 ,7天最高 ,2 1天降低至术前以下。心肌ANP水平显著低于对照组。血浆和心肌ANP水平与心包粘连增厚和ATPase染色等级均呈显著负相关。组织病理检查示心包粘连增厚和心肌损害。结论 :可认为ANP参与心包炎的发生发展过程 ,ANP对临床心包炎诊治有重要意义。

Objective:to investigate damages of the changes of histopathology and its relations of pericarditis and myocardiosis Method:24 rabbits were divided into two groups.30% wrea were injected into 13 rabbits' pericardial carith of Group Ⅰ.0.9% natrium chloride were injected into 11 rabbits′ penicardial canity of GroupⅡas control.Changes of ANP in blood and myocardial tissues were measured,and levels of ANP in blood and myocardial tissues were measured.Changes of pericardial and myocardial histopatology were observed. Result:The plasma concentration of ANP increased initially on the right day after operation.The concentration reached its peak on the 7th day after operation and decreased gradually day after day.On the 21st day it reached the lower level before operation.The level of myocardial ANP in Group Ⅰ was lower than thast in Group Ⅱ.The level of myocardial ANP was related to the degree of actity of ANPase in myocardium and pericardial daheion thickened. Conclusion:ANP can take part in the period of pericarditis and it has important significance of the diagnosis and treatment of pericarditis.