右美托咪定复合芬太尼联合异丙酚在无痛纤支镜检查中的效果及安全性研究

Effect and safety of dexmedetomidine combined with fentanyl and propofol in painless bronchoscopy

目的 研究右美托咪定复合芬太尼联合异丙酚在无痛纤支镜检查中的效果及安全性.方法 选择我院接受无痛纤支镜检查和治疗的患者作为研究对象,随机分为观察组（丙泊酚-芬太尼-右美托咪定复合麻醉）和对照组（丙泊酚-芬太尼复合麻醉）,观察两组生命体征、咳嗽反射及不良反应情况.结果 观察组SBP、DBP、HR均明显低于对照组,SpO2均高于对照组,差异有统计学意义（P＜0.05）;观察组剧烈咳嗽、一过性高血压、心律失常、躁动、寒战、苏醒延迟、恶性呕吐的发生例数以及0 ～ 10 min、10 ～ 20 min平均咳嗽次数均明显少于对照组,差异有统计学意义（P＜0.05）.结论 右美托咪定复合芬太尼联合异丙酚有利于稳定生命体征、控制咳嗽反射、减少不良反应,在无痛纤支镜检查中具有积极的应用价值.

Objective To study the effect and safety of dexmedetomidine combined with fentanyl and propofol in painless bronchoscopy. Methods Patients with painless bronchoscopy for examination and treatment in our hospital were chosen as study objects, and they were randomly divided into observation group which was given propofol-fenta- nyl-dexmedetomidine anesthesia and control group using propofol-fentanyl anesthesia. The vital signs, cough reflex and adverse reactions were observed. Results The SBP, DBP, HR were significantly lower in the observation group than those in the control group and SpO2 were higher（ P 〈 0. 05 ）. The occurrence rate of severe coughing, transitional hyper- tension, arrhythmia,restlessness, shivering, delayed recovery, malignant vomiting and average cough frequency at 0 - 10 min, 10 -20 min were significantly less in the observation group than those in the control group（ P 〈 0. 05 ）. Conclu- sion Dexmedetomidine combined with fentanyl and propofol is in favour of stabilizing vital signs, and can control the cough reflex, and reduce adverse reactions in painless bronchoscopy with a positive value.