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纳洛酮联合醒脑静治疗急性重度乙醇中毒的疗效观察 被引量:8

Efficacy of naloxone combined with xingnaojing treatment for acute severe alcohol poisoning
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摘要 目的探讨纳洛酮联合醒脑静注射液治疗急性重度乙醇中毒的临床效果及安全性。方法选取120例急性重度乙醇中毒患者,按入院顺序随机分为2组,每组60例。两组患者均给予补液、利尿及维持酸碱平衡、纠正电解质紊乱等对症支持治疗,对照组在此基础上采用醒脑静治疗,醒脑静每日总量不超过100 mL,观察组在对照组的基础上加用纳洛酮,纳洛酮每日总量不得超过4 mg。观察两组患者用药后症状缓解时间、症状消失时间、意识恢复时间,记录平均住院时间,并对两组患者进行疗效评定。在治疗期间严密观察并记录两组患者不良反应发生情况。结果观察组症状缓解时间、症状消失时间、意识恢复时间及住院时间均明显短于对照组,两组比较差异有统计学意义(P<0.05)。观察组治疗总有效率为98.33%,对照组为88.33%,两组比较差异有统计学意义(P<0.05)。观察组不良反应4例(6.67%),1例恶心,3例心律失常;对照组不良反应2例(3.33%),2例恶心。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论纳洛酮联合醒脑静治疗急性重度乙醇中毒可在更短的时间里改善患者循环、呼吸系统症状,疗效显著,不良反应少,可以显著缩短住院时间,值得临床推广应用。 Objective To investigate the efficacy and safety of naloxone combined with xingnaojing injection treatment for acute severe alcohol poisoning. Methods 120 cases of acute severe alcohol poisoning patients were ran- domly divided into two groups,60 cases in each group. The patients of the two groups were both treated with rehydra- tion,diuretic and maintaining acid-base balance, correcting of electrolyte disorders, symptomatic and supportive treat- ment,while control group used xingnaojing treatment, the amount of xingnaojing was less than 100 mL/d, treatment group used naloxone,the amount of naloxone was less than 4 mg/d. The symptom relief time, symptoms disappear- ance,consciousness recovery time and hospital staytime were observed and recorded, and the curative effect was as- sessed. The adverse reactions during treatment was closely observed and recorded of the two groups. Results The symptom relief time, symptoms disappearance, consciousness recovery time and hospital staytime were significantly shorter than those of control group, there was significant difference between the two groups ( P 〈 0. 05 ). The total effec- tive rate of observation group was 98.33% ,while it was 88.33% of control group,there was significant difference be- tween the two groups (P 〈 0. 05 ). Observation group had 4 cases (6.67%) of adverse reactions with 1 case of nausea and 3 cases of arrhythmia,control group had 2 cases (3.33%) of adverse reactions with 2 cases of nausea,there was no significant difference in adverse reactions between the two groups ( P 〉 0. 05 ). Conclusion Naloxone combined with xingnaojing treatment for acute severe alcohol poisoning has a shorter period of time to improve the circulation and respiratory symptoms with fewer adverse reactions and shorter hospital staytime,it is worthy of clinical application.
作者 陈毓 吴德军
出处 《实用药物与临床》 CAS 2013年第11期1030-1032,共3页 Practical Pharmacy and Clinical Remedies
关键词 纳洛酮 醒脑静 乙醇中毒 Naloxone Xingnaojing Alcoholism
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