派罗欣联合利巴韦林治疗慢性丙型病毒性肝炎不良反应的观察及护理

Observation and nursing of the adverse reactions of pegasys combined with ribavirin treatment for chronic HCV

目的观察派罗欣(聚乙二醇干扰素α-2a)联合利巴韦林治疗慢性丙型病毒性肝炎(HCV)患者时出现的不良反应,及时提供有效的护理措施和健康教育,提高患者的治疗依从性、生活质量和对护理工作的满意度。方法在60例慢性丙型病毒性肝炎患者进行抗病毒治疗期间,做好心理护理的同时,针对可能出现的各种不良反应提前宣教,并及时采取有效的护理措施,减轻患者不适。结果在护理过程中重视患者心理问题,做好心理护理和各种并发症的护理,使60例患者建立了良好的用药依从性,为取得较好的治疗效果打下坚实的基础。派罗欣联合利巴韦林治疗慢性丙型病毒性肝炎最常见的不良反应是流感样症状、胃肠道反应、血液系统损害、精神神经系统症状等,其中,中性粒细胞减少、胃肠道反应及血红蛋白、血小板下降等可以导致干扰素及利巴韦林减量甚至停药,从而影响抗病毒疗效。结论通过适当的护理干预减轻患者的负面情绪,可提高患者的治疗依从性和护理工作的质量,患者对护理工作予以肯定,满意度提高。

Objective To observe the adverse reactions of pegasys combined with ribavirin treatment for chro- nic HCV,provide effective nursing intervention and health education to the patients to increase the patients＇ compliance to the treatment and the satisfactory to the life quality and nurse work. Methods During the period of anti-virus treat- ment of 60 patients with chronic HCV, health education in advance aiming at adverse reaction was carried out and effec- tive nurse intervention to relieve the discomfort of the patients was taken while mental nursing was performed. Results During the nursing work, we took the mental problem seriously and paid attention to the mental nursing and compli- cation nursing which made a good compliance of the 60 patients to the drug. Thus a solid foundation would be laid to obtain a good result of treatment. The common adverse reactions of pegasys combined with ribavirin treatment for chro- nic HCV were flu like symptom, gastrointestinal reaction, blood system damage and mental problem etc. The decrease of neutrophilic granulocyte, hemoglobin,blood platelet and gastrointestinal reaction would lead to the decrement of pe- gasys and ribavirin which could affect the effect of treatment. Conclusion The compliance of the patients and the nursing quality are raised by nursing intervention to decrease the patients＇ negative emotion, the patients are satisfied with our work.