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脉压对糖尿病人群肾功能的影响 被引量:2

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摘要 目的探讨脉压(PP)对糖尿病人群肾功能的影响。方法以健康查体的101 510例开滦集团职工中的8 942例空腹血糖≥7.0 mmol/L或<7.0 mmol/L但已确诊为糖尿病、正在使用降糖药物的人群作为观察对象,按PP分为PP<60 mmHg组和PP≥60 mmHg组,采用改良的MDRD公式计算估计肾小球滤过率(eGFR),对两组人群的肾功能特点及其影响因素进行比较分析。结果 (1)与PP<60 mmHg组相比,PP≥60 mmHg组患者尿蛋白阳性检出率增加(23.4%vs 16.6%,P<0.01),血肌酐水平升高[(97.04±34.69)vs(93.15±33.30)μmol/L,P<0.01],eGFR水平降低[(93.23±36.97)vs(100.63±35.32)mL/(min·1.73 m2),P<0.01]。(2)同一PP水平,女性人群的eGFR水平低于男性人群,差异有统计学意义(P<0.05)。(3)多变量logistic回归分析校正年龄、性别、TG、LDL-C、空腹血糖、尿蛋白后,显示高PP为eGFR下降的危险因素。结论高PP是糖尿病人群肾功能损害的危险因素。
出处 《广东医学》 CAS CSCD 北大核心 2013年第21期3276-3279,共4页 Guangdong Medical Journal
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