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Th17/Treg失衡与肝脏疾病关系的研究进展 被引量:1

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摘要 肝脏疾病一直严重危害人类健康,目前研究发现肝脏疾病的发生、发展与免疫应答密切相关,但其确切免疫学机制仍不十分清楚.Th17和Treg细胞是体内一群重要的T细胞亚群,两者具有共同的起源,介导炎症反应的Th17细胞和介导免疫耐受的Treg细胞在功能和分化过程等相互对抗,研究Th17/Treg失衡与肝脏疾病的关系,以加深对其认识,拓宽进一步寻求肝脏疾病治疗的新策略和对策有重要意义.
出处 《广东医学》 CAS CSCD 北大核心 2013年第21期3345-3347,共3页 Guangdong Medical Journal
基金 贵州省科技厅社会发展攻关项目(编号:黔科合SY字[2011]3048号)
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  • 1ROMAGNANII S,MAGGI E,LIOTTA F,et al.Properties and origin of human Th17 cells[J].Mol Immunol,2009,47(1):3-7.
  • 2COSMI L,DE PALMA R,SANTARLASCI V,et al.Human interleukin 17-producing cells originate from a CD161+CD4+T cell precursor[J].J Exp Med,2008,205(8):1903-1916.
  • 3ANNUNZIATO F,COSMI L,LITTA F,et al.The phenotype of human Th17 cells and their precursors,the cytokines that mediate their differentiation and the role of Th17 cells in inflammation[J].Int Immunol,2008,20(11):1361-1368.
  • 4LANGRISH C L,CHEN Y,BLUMENSCHEIN W M,et al.IL-23 drives a pathogenic T cell population that induces autoimmune inflammation[J].J Exp Med,2005,201(2):233-240.
  • 5BRUSTLE A,HEINK S,HUBER M,et al.The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4[J].Nat Immunol,2007,8(9):958-966.
  • 6CHUNG Y,CHANG S H,MARTINEZ G J,et al.Critical regulation of early Th17 cell differentiation by interleukin-1 signaling[J].Immunity,2009,30(4):576-587.
  • 7PARHAM C,CHIRICA M,TIMANS J,et al.A receptor for the heterodimeric cytokine IL-23 is composed of IL-12R beta1 and a novel cytokine receptor subunit,IL-23R[J].J Immunol,2002,168(11):5699-5708.
  • 8WEAVER C T,HARRINGTON L E,MANGAN P R,et al.Th17:an effector CD4 T cell lineage with regulatory T cell ties[J].Immunity,2006,24(6):677-688.
  • 9MCKARNS S C,SCHWARTZ R H.Distinct effects of TGF-beta 1 on CD4+ and CD8+T cell survival,division,and IL-2 production:a role for T cell intrinsic Smad3[J].J Immunol,2005,174(4):2071-2083.
  • 10ZHANG J Y,ZHANG Z,LIN F,et al.Interleukin-17-producing CD4+ T cells increase with severity of liver damage in patients with chronic hepatitis B[J].Hepatology,2010,51(1):81-91.

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