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老年高血压左室肥厚患者血浆心肌营养素-1和N端脑钠肽的变化 被引量:6

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摘要 目的探讨血浆心肌营养素-1(CT-1)联合N端脑钠肽(NT-pro BNP)在老年高血压左室肥厚(LVH)患者中的作用和意义。方法选择年龄≥65岁的高血压患者62例,分为单纯高血压组(n=30)和LVH组(n=32),另选健康体检老人(n=26)为对照组。应用GE Vivid 7进行超声心动图检查,按Devereux公式计算左室质量指数(LVMI)。血浆CT-1水平采用双抗体夹心酶联免疫吸附法(ELISA)测定,NT-pro BNP含量应用锐普荧光干式定量分析仪检测。结果 LVH组血浆CT-1、NT-pro BNP水平明显高于单纯高血压组和对照组(P<0.01)。Pearson相关分析显示,LVH组血浆CT-l水平与LVMI值、NT-pro BNP含量呈正相关(r=0.630,P<0.01;r=0.718,P<0.01)。结论老年高血压LVH患者血浆CT-1水平明显升高,并与LVMI和NT-pro BNP有较好的相关性。联合检测血浆CT-1和NT-pro BNP将有助于提高老年高血压LVH的诊断。
出处 《广东医学》 CAS CSCD 北大核心 2013年第22期3419-3420,共2页 Guangdong Medical Journal
基金 河南省教育厅科技攻关项目(编号:2007320028)
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参考文献12

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