超重对哮喘患者肺功能及呼出气一氧化氮的影响

Effect of overweight on lung function and fractional exhaled nitricoxide of asthma patients

目的:探讨天津地区哮喘人群的超重对肺功能、哮喘控制水平和气道炎症的影响。方法:将研究对象分为体质量正常和超重(BMI≥24 kg/m2并且<28 kg/m2)2组,测定所有对象的BMI、肺功能和呼出气一氧化氮(FENO)含量,开始规范治疗后哮喘患者记录哮喘日记,按照GINA指南进行ACT(哮喘控制测试表)评分。结果:超重组的1称钟用力呼气量、1秒钟用力呼气量占预计值百分比较体质量正常组显著降低,同时气道阻力显著增高(P值均<0.05)。两组中哮喘控制良好(ACT≥20)的患者人数与控制不佳(ACT<20)的患者人数相比后,超重组的比值显著低于正常体质量组(0.92∶1.86,P<0.05)。两组的FENO含量没有显著差别(P>0.05)。结论:在天津地区哮喘人群中,超重可影响肺功能(主要表现在肺通气功能)及导致哮喘控制不佳,但并不引起FENO含量的改变。

Objective：To explore the impact of overweight on pulmonary function,asthma control,and airway inflammation in asthmatic population of Tianjin.Methods：Patients were divided into normal weight and overweight （BMI ≥ 24 kg/m2 and〈28 kg/m2）groups.BMI,pulmonary function and fractional exhaled nitric oxide （FENO） were measured in all patients.Patients recorded asthma diary after standard treatment,and ACT score values were rated according to the GINA guidelines.Results：Compared to normal weight group,overweight group had lower FEV1 and FEV1%,and higher airway resistance （P〈0.05 for each comparison）.The ratio between the number of patients with well-controlled asthma （ACT ≥ 20） and that of patients with poorly-controlled asthma（ACT〈20） was significantly lower in overweight group than normal weight group （0.92：1.86,P〈0.05）.No difference was observed in FENO values between the two groups （P〉0.05）.Conclusion：In asthmatic population of Tianjin,overweight can influence pulmonary function （mostly on pulmonary ventilation function）and cause poor asthma control but not lead to the change of FENO.