乙酰乙酸乙酯合成1,1-二苯基-1-丁烯-3-酮的研究

A Study of the Synthesis of 1,1-Diphenyl-1-Buten-and 3 Ketones Through Acetoacetic Ester

采用乙酰乙酸乙酯的酯基与格氏试剂反应生成叔醇,再使叔醇消去反应生成α,β-不饱和酮,即1,1-二苯基-1-丁烯-3-酮。实验过程中采用了典型保护基团环状缩酮来保护酮羰基,使酮羰基在与格氏试剂反应中免受干扰。

Acetoacetate ester reacts with a Grignard reagent, producing tertiary alcohol, and then the elimination reaction of the tertiary alcohol genertates α, β - and unsaturated ketone, i.e. 1,1- diphenyl -1-buten -and 3 Ketones. During the experiment a typical cyclic ketal protecting group is used to protect the keto carbonyl group and prevent the interference of the grignard reagent with keto carbonyl group.