摘要
目的：探讨血清结合珠蛋白的遗传多态性与呼吸系统几种常见疾病的关联。方法：应用聚丙烯酰胺凝胶垂直平板电泳技术，分析四川泸州地区肺气肿、支气管哮喘和肺癌患者的HP表型分布。结果：三种疾病患者的HP1基因频率都显著高于正常对照组。结论：HP1基因与呼吸系统常见的三种疾病发生有关，可能是促使机体对这三种疾病易感的遗传因子。
Objcetive: To investigate the relationship between Hp genetic polymorphism and different kinds of respiratory disease. Mothods: The phenotypes of haptoglobin were studied in 291 patients with three different respiratory diseases, bronchial asthma, pulmonary emphysema, and lung cancer. The gene frequencies in different group of patients were calculated and compared with controls. Result: The Hp gene freguency in patients was significantly higher. Conclusion: The results suggested that Hp allele may be related to the above 3 kinds of respiratory diseaes,and Hp allele is probably a factor in the development of respiratory diseases.
出处
《泸州医学院学报》
1999年第6期485-486,共2页
Journal of Luzhou Medical College
关键词
呼吸系统疾病
结合珠蛋白
遗传多态性
肺气肿
Haptoglobin
Polymorphism (genetics)
Pulmonary
Emphysema
Asthma
Lung cancer
