Bcl-2基因与子宫内膜增生发病关系的研究

STUDY ON RELATIONSHIP BETWEEN BCL－2 AND ENDOMETRIAL HYPERPLASTIC DISEASES

目的：探讨凋亡抑制基因bcl－2在子宫内膜增生发病过程中的作用。方法：采用免疫组化法检测89例子宫内膜增生病例和20例正常月经周期子宫内膜组织bcl－2表达特征。结果：子宫内膜增生病例bcl－2表达明显强于正常月经周期子宫内膜；随子宫内股增生病变发展如bcl－2表达逐渐减弱（P＜0．05）；在不同程度不典型子宫内膜增生病例中其bcl－2表达水平无显著差异（P＞0．05）。结论：bcl－2抑制细胞凋亡的机制可能在子宫内膜增生病变发生早期起作用。

Objectlve:To study the relationship beween the expression of bcl-2 and the development of endometrial hyperplasia,atypical hyperplasia and endometrial carcinorna.Methods:Bcl-2 expression was detected in the endornetrium from 89 cases of endometrial hyperplasia and 20 cases of normal endometrium by using immunohistochemical ABC technique.Results:Bcl-2 scores were lower in normal endometium than in hyperperplastic endometrium,the differences among different types of hyperplastic endometrium were significant,P＜ 0．05，but not among the atypical hyperplastic endometrium P＞ 0． 05．Concluslon:It’s suggested from the study that bcl-2 expression might play an important role in endometrial hyperplasia by inhibiting apoposis．