樟树茎与沉香醇提物药理作用对比研究

Contrastive Study on the Pharmacological Action of Alcohol Extract Caulis Cinnamomi Camphorae and Lignum Aquilariae Sinensis

目的:对樟树茎与沉香醇提物的药理作用进行对比研究,为樟树茎能否替代沉香提供科学依据。方法:采用热板法、扭体法、浓氨水致咳法、磷酸组胺致喘法研究沉香与樟树茎的醇提物的镇痛、止咳、平喘作用。结果:与空白组比较,樟树茎与沉香的醇提物均对小鼠有显著的镇痛作用(P<0.01),二者之间无显著性差异(P>0.05);均对小鼠有显著的止咳作用(P<0.05),二者之间无显著性差异(P>0.05);均对磷酸组胺致喘的豚鼠有显著的平喘作用(P<0.05),二者之间无显著性差异(P>0.05)。结论:樟树茎与沉香醇提物的镇痛、止咳、平喘作用相似;樟树茎可能取代沉香在中药临床上对于镇痛、止咳、平喘疗效的应用。

Objective：To comparative study the pharmacological effects on alcohol extract from Caulis cinnamomi camphorae（CCC） and Lignum aquilariae sinensis （LAS）, so as to provide scientific basis for CCC taking the place of LAS or not. Methods：We use the hot- plate method, torsion body method, cough by ammonia spirit method and histamine induced asthma method to observe the analgesia, re- lieving cough and relieving asthma effect of the alcohol extract from CCC and LAS. Results ： The alcohol extract of CCC and LAS all had prominent analgesia effect on mice（P 〈 0.01 ） ,and they had nothing different at this point（ P 〉 0..05 ） ;While using the cough by am- monia spirit method, the alcohol extract of CCC and LAS all can apparently relieving cough （ P 〈 0.05 ）, and they had nothing different （ P 〉 0.05 ） ; The alcohol extract of CCC and LAS all have obviously relieving asthma （ P 〈 0.05 ）, and there was no significant differ- ence（P 〉 0.05）. Conclusion： The alcohol extract of CCC and LAS have prominent analgesic, relieving cough and relieving asthma effects, and in the sense of analgesic, relieving cough and relieving asthma. CCC maybe nerfeetlv instead of I,AS in clinical.