帕金森病认知障碍的静息态fMRI研究

The resting state fMRI study of patients with Parkinson's disease associated with cognitive dysfunction

帕金森病(PD)是最常见的锥体外系疾病,而PD伴发认知障碍的发生率也逐渐提高。近年来静息态功能磁共振成像(fMRI)技术的快速发展,提示PD病人认知障碍可能与神经网络破坏有关。应用神经网络拓扑结构分析,可能会进一步深入揭示PD病人认知障碍的神经病理机制与认知回路损伤之间的关系。PD病人认知障碍的静息态fMRI研究能为该病的预防、及时诊断和治疗提供理论指导。

Parkinson＇s disease （PD） is the most common neurodegenerative cause of Parkinsonism, but the high morbidity of PD accompanied cognitive dysfunction hasn＇t drawn enough attention by the clinicians. With the rapid development of the resting state functional MRI （fMRI） technique, the cause of PD patients with cognitive dysfunction may be associated with the damage of functional connectivity of the motor networks and the cognitive networks. The relationship between neuropathologic mechanism of PD patients with cognitive dysfunction and impaired cognitive circuits will be disclosed by building the changes of brain topological structure in patients. The resting state fMRI study can provide the rationale for prevention, diagnosis and treatment of PD.