奥曲肽持续泵入治疗重症胰腺炎38例

Clinical Efficacy Octreotide Continuous Pumping in Treating Severe Acute Pancreatitis in 38 Cases

目的探讨奥曲肽持续泵入治疗重症胰腺炎的临床疗效。方法将收治的重症胰腺炎患者76例按随机数字表法随机分为研究组和对照组,其中对照组仅采用常规禁食、胃肠减压,给予泮托拉唑、丹参、低分子右旋糖酐,研究组在此基础上采用奥曲肽持续泵入治疗。比较两组患者的临床疗效、症状体征消失时间及不良反应发生率。结果研究组的显效率和总有效率均明显高于对照组(χ2=5.28,4.55,P<0.05);腹痛腹胀消失时间、血淀粉酶恢复时间、尿淀粉酶恢复时间、胰腺水肿改善时间、白细胞恢复时间均较对照组明显缩短(t=3.62,4.96,3.05,3.11,3.67,P<0.05);不良反应发生率明显低于对照组(χ2=3.95,P<0.05)。结论奥曲肽持续泵入治疗重症胰腺炎具有良好的临床疗效,不良反应发生率低,值得临床推广。

Objective To investigate the clinical effect of octreotide continuous pumping in treating severe acute pancreatitls. Methods Seventy- six patients with severe acute pancreatitis were randomly divided into the study group and the control group according to the random number table. The control group was only treated with routine fasting, gastrointestinal decompression, pantoprazole, radix salviae mihiorrhizae and low molecular dextran, while the study group was treated with octreotide continuous pumping based on the above treat- ment. The clinical efficacy, symptoms and signs disappearance time and the occurrence rate of adverse reactions were compared between two groups. Results The significantly effective rate and the total effective rate of the study group were significantly higher than those of the control group（x2 =5.28, 4. 55, P〈 0.05）; the disappearance time of abdominal pain and abdominal distension, recovery time of blood amylase, urine amylase recovery time, pancreatic edema improvement time and white blood cell recovery time in the study group were significantly shortened compared with the control group （ t = 3.62, 4.96, 3.05, 3.11,3.67, P 〈 0.05） ; the occurrence rate of adverse reactions in study group was significantly lower than that of the control group （X2 = 3.95, P 〈 0. 05）. Conclusion Octreotide continuous pumping has good clinical curative effect and low occurrence rate of adverse reactions in treating of severe acute pancreatitis, which is worthy of clinical promotion.