左氧氟沙星联合阿奇霉素治疗呼吸道合胞病毒感染30例

Levofloxacin Combined with Azithromycin in Treating Respiratory Syncytial Virus Infection in 30 Cases

目的观察左氧氟沙星联合阿奇霉素对呼吸道合胞病毒感染(RSV)和哮喘患者淋巴液、血液中T细胞亚群及干扰素γ、白细胞介素-4(IL-4)的变化。方法选择60例呼吸道合胞病毒和哮喘感染的患儿,随机分为联合组和对照组,各30例。联合组采用左氧氟沙星联合阿奇霉素治疗,对照组单纯使用左氧氟沙星,治疗周期为30 d。治疗前后均采用流式细胞仪检测外周血T细胞亚群,酶联免疫吸附法(ELISA)检测IL-4、干扰素γ水平。结果两组血液中CD3+,CD4+,IL-4,转化型生长因子(TGF)β1水平均较治疗前明显降低(P<0.05),而干扰素γ水平明显升高(P<0.05)。组间比较对照组CD3+,CD4+,IL-4,转化型生长因子(TGF)β1水平均较联合组高,干扰素γ低于联合组(P<0.05)。联合组中发生哮喘的患儿有5例(16.67%),少于对照组的10例(33.33%),差异具有统计学意义(P<0.05)。结论左氧氟沙星联合阿奇霉素治疗RSV感染引起的毛细支气管炎,可通过作用于患者免疫细胞提高治疗效果。

Objective To observe the changes of lymph, blood T cell subsets, interferon gamma eytokines and interleukin- 4（IL- 4） in levofloxacin combined with azithromycin in treating the patients with respiratory syncytial virus （RSV） infection and the patients with asthma. Methods Sixty children patients with RSV infection and asthma were selected and randomly divided into the combined group and the control group. The combined group adopted levofloxacin combined with azithromycin, while the control group simply used levofloxacin with the treatment cycle of 30 d. The flow cytometry instrument was adopted to detect peripheral blood T cell subsets before and alter treatment and the enzyme- linked immunosorbent assay（ELISA） was used to detect IL-4 and interferon- gamma levels. Results Blood CD3＋, CD4＋, IL-4, transformative growth factor （TGF） B1 levels after treatment in both two groups were significantly decreased compared with before treatment（ P 〈 0.05）, while the interferon - gamma level was significantly increased（ P 〈0. 05） . The CD3 ＋, CD4＋. II, - 4, TGF-BI levels after treatment in the control group were higher than those in the combined group, while the interferon-gamma level was lower than that in the combined group（P 〈0. 05）. Five cases（16.67% ） of asthma in the combined group and 10 cases（33.33%） of asthma in the control group occurred（P〈0. 05）. Conclusion Levofloxacin combined with azithromycin for treating capillary bronchitis caused by RSV infection can improve the curative effect by acting on the immune cells.