阿维A联合环孢素治疗儿童脓疱型银屑病60例

Clinical Efficacy of Acitretin Combined with Cyclosporine in Treating Children Pustular Psoriasis in 60 Cases

目的观察阿维A联合环孢素治疗儿童脓疱型银屑病的临床疗效和安全性。方法将120例脓疱型银屑病患者随机分为两组,治疗组给予环孢素和阿维A联合治疗,对照组仅给予环孢素口服治疗。观察两组疗效和不良反应。结果治疗12周后,治疗组痊愈42例,显效12例,有效率为90.00%;对照组痊愈30例,显效12例,有效率为70.00%。两组比较,差异有统计学意义(P<0.05)。治疗组常见不良反应是干燥型唇炎和皮肤瘙痒,对患儿的身高和体重无不良影响;对照组出现肝、肾功能降低等不良反应。结论阿维A联合环孢素治疗儿童脓疱型银屑病疗效肯定、不良反应较轻,值得临床推广。

Objective To evaluate the clinical efficacy and safety of acitretin combined with cyclosporine in treating of pustular psoriasis in children. Methods Twenty patients with pustular psoriasis were randomly divided into two groups,the treatment group used acitretin and cyclosporine, while the control group, used cyclosporine alone. The efficacy and adverse reaction of the two groups were ob- served. Results After 12 weeks treatment,42 cases in the treatment group were cured,12 cases were significantly effective,total effec- tive rate was 90.00%. 30 cases in the control group were cured,12 cases were significantly effective,total effective rate was 70.00%, it had statistical differences between the two groups （P〈0.05）. The most common ADR in the treadment group was dry chei｜itis and skin pruritus,and no ADR on height and weight of children. The hepatic renal function of children were partly affected in the control guoup. Conclusion Acitretin combined with cyclosporine has good effect in treating children pustular psoriasis, and ADR was slipht, which is worthy of clinical promotion.