降钙素原与超敏C反应蛋白在NICU医院感染监测中的应用

Procalcitonin and High Sensitive C-reactive Protein in the Monitoring of Nosocomial Infection in NICU

目的:探讨监测降钙素原(PCT)与超敏C反应蛋白(HsCRP)水平在NICU医院感染监测中的诊断价值及临床意义。方法:将53例存在医院感染临床表现的新生儿分为感染组22例与高危组31例,选取同期住院无感染征象、未使用抗生素治疗的51例新生儿患儿作为对照组。监测各组PCT、HsCRP水平,治疗后复查上述指标。结果:感染组与高危组血清PCT分别为(30.65±7.27)μg/L、(21.53±6.46)μg/L,HsCRP分别为(17.52±6.43)mg/L、(12.96±4.45)mg/L,高于对照组的(0.31±0.28)μg/L、(1.87±0.41)mg/L,治疗后两组PCT、HsCRP水平明显下降与治疗前比较差异有统计学意义(P<0.05)。PCT、HsCRP联合检测的阳性率(92.93%)高于PCT(85.21%)和HsCRP(67.42%)单独检测的阳性率(P<0.05)。结论:将PCT、HsCRP纳入NICU医院感染监测,可以提高医院感染的早期诊断率,并有助于监测医院感染患儿的病情发展及预后。

Objective： To investigate the level of procalcitonin （PCT） and high sensitive C-reactive protein （HsCRP） in the monitoring of nosocomial infection in NICU. Methods： Fifty-three neonates with nosocomial infection were divided into an infection group （22 cases） and a high risk group （31 cases）. 51 newborns hospitalized at the same time without infections were set as the control group. PCT and HsCRP of each group were monitored during and after treatment. Results ： The serum PCT and HsCRP levels of the infection group and the high risk group were higher than those of the control group. After the treatment PCT and HsCRP levels of the infection group and the high risk group decreased significantly. Positive rate of combined detection of PCT and CRP was significantly higher than that of single detection of PCT or HsCRP. Conclusions： Detection of PCT and HsCRP in nosocomial infection monitoring in NICU can improve the early diagnosis rate of nosocomial infection, and help to monitor the conditions and prognosis of children with nosocomial infection.