环孢素A治疗小儿再生障碍性贫血的临床疗效

Effect of Cyclosporin A in the Treatment of Aplastic Anemia in Children

目的探讨环孢素A(CsA)治疗小儿再生障碍性贫血的临床疗效。方法选取2010年1月—2013年6月我院收治的再生障碍性贫血患儿89例,将患儿随机分为CsA治疗组(49例)和常规治疗组(40例)。常规治疗组给予中成药再造生血片进行治疗,CsA治疗组在常规治疗组基础上,加用CsA胶囊。观察两组疗效,给药前后对两组患儿进行外周一般血常规检查,并记录患儿不良反应发生率。结果 CsA治疗组总有效率为85.7%(42/49),高于常规治疗组的52.5%(21/40)(P<0.05)。治疗前,两组患儿白细胞、血小板和血红蛋白等指标比较,差异无统计学意义(P>0.05)。治疗后,CsA治疗组患儿白细胞、血小板、血红蛋白、不良反应发生率等指标均高于常规治疗组(P<0.05)。结论 CsA对小儿再生障碍性贫血具有显著疗效,虽然有一定不良反应,但停药后均会自行消失,不会影响治疗效果。因此,CsA在治疗小儿再生障碍性贫血上应该有更广泛的运用。

Objective To Explore the effect of cyclosporine A （CsA） in the treatment of aplastic anemia in children. Methods 89 children with aplastic anemia were selected in our hospital from January 2010 to June 2013, the children were ran- domly divided into CsA- treated group （49 cases） and the conventional treatment group （40 cases）. The conventional treat- ment group was given medicine for treatment and recycling blood film, the CsA treatment group was given CsA capsules based on the conventional treatment group. The wffects were observed, The normal peripheral blood cells of two groups were examined before and after administration, and incidence of adverse reactions were recorded. Results The total effective rate of CsA - treated group was 85.7% （42/49）, higher than that of conventional treatment group of 52. 5% （21/40） （P 〈 0.05）. Before the treatment, the white blood cells, platelets, and hemoglobin and other indicators of two groups were compared, the difference were not statistically significant （P 〉 0.05）. After the treatment, the white blood cells, platelets, hemoglobin, incidence of adverse reactions and other indicators of CsA - treated group were higher than those of conventional treatment group （P 〈 0. 05 ）. Conclusion CsA in children with aplastic anemia has a significant effect, although there are some adverse reactions, but after stopping, will disappear on their own, will not affect the treatment effect. Therefore, CsA in the treatment of children with aplastic anemia there should be more widely used.