皮尔复、甲硝唑或右旋糖酐对腹腔粘连的实验研究

Experimental study on postoperative abdominal adhesion treatment with Perfect Solution. Metronidazole and Deatran

目的探讨用皮尔复、甲硝唑或右旋糖酐灌注腹腔对术后腹腔粘连形成和腹腔粘连松解后粘连再形成的影响。方法本地犬 48只 ,随机分成生理盐水组、皮尔复组、甲硝唑组和右旋糖酐组 ,每组 12只。每次于术毕前相应组分别腹腔灌注生理盐水、皮尔复、甲硝唑、右旋糖酐各 2 5ml。每间隔 2周做 1次腹腔手术 ,并观察腹腔粘连情况 ,共观察 4次。结果皮尔复 (P <0 0 0 5 )、甲硝唑 (P <0 0 5 )和右旋糖酐 (P <0 0 5 )腹腔灌注能显著降低腹腔术后腹腔粘连的发生率。结论皮尔复、甲硝唑或右旋糖酐腹腔灌注是一种安全的用药途径 ,均有降低术后腹腔粘连的作用 ,以皮尔复的效果最显著。

Objective To evaluate the effect of Perfect Solution Metronidzole and Dextran for prevention and treatment post operative abdominal adhesion. Methods 48 dogs were randomized into normal saline, Perfect Solution,Meronidazole and Dextran groups. Eact group was 12 dogs. The abdominal cavity operation was performed every interval two weeks. The abdominal adhesion was observed. The corresponding 25ml solution was perfused into four groups before closed abdominal cavity respectively. 4 times were observed in all. ResultsThe Perfect Solution, Metronidazole and Dextran perfuse abdominal cavity could be significantly decreased the abdominal adhesion rate after abdominal operation.Conclusion Perfect Solution,Metronidazole and Dextran perfusion were safe in preventing and treating abdominal adhesion of post operation.