利拉鲁肽对2型糖尿病患者C-肽水平的影响

The lalu peptide c-peptide levels in patients with type 2 diabetes

目的探讨药物利拉鲁肽对2型糖尿病患者C-肽水平的影响。方法采用酶联免疫法测定T2DM患者及正常人C-肽水平,分析空腹血糖、血糖、糖化血红蛋白、C肽(空腹、餐后l h、餐后2 h)等指标,调整剂量FPG,观察利拉鲁肽治疗前后24周以上T2DM患者血浆C-肽水平变化,并分析结果。结果治疗组和对照组患者治疗前FPG、2PhPG、H bIAC明显高于正常组(P<0.1),C肽(空腹、餐后l h、餐后2 h)低于正常组(P<0.1)。治疗后治疗组和对照组FPG、2 h PPG、H bI AC明显下降均已达标,与治疗前相比有显著差异(P<0.5),且治疗组下降幅度明显优于对照组(P<0.5)。治疗后、治疗组C肽与治疗前相比明显提高(P<0.1),对照组C肽较治疗前亦提高(P<0.5),且治疗组明显高于对照组(P<0.5)。结论利拉鲁肤不仅有降血糖,减轻体重,低血糖风险低,有利于维持血糖稳定,最主要是显著调节胰岛细胞功能,促进胰岛p细胞新生及分化,减少胰岛日细胞凋亡,从而增加胰岛细胞数量,增加C-肽分泌。

Objective To study medication liraglutide in patients with type 2 diabetes, C-peptide levels.Methods Enzyme linked immunosorbent assay in patients with T2DM and normal C-peptide levels, fasting glucose analysis, blood glucose, glycosylated hemoglobin, C peptide （fasting, postprandial lh, postprandial 2 h） and other indicators, adjust the dose FPG, concept Cha Lila Lu peptide than 24 weeks before and after treatment in patients with T2DM plasma C-peptide levels, and analyze the results.Results The treatment group and the control group of patients before treatment FPG, 2PhPG, H blAC significantly higher than the normal group （P 〈0.1）, C peptide （fasting, postprandial lh, postprandial 2h） lower than normal group （P〈0.1）.The treatment group and the control group FPG, 2 hPPG, HblAC have decreased compliance, compared with before treatment were significantly different（P〈0.5）,and decreased significantly in the treatment group than the control group （P〈0.5）.After treatment, the treatment group compared with before treatment C-peptide was significantly increased （P〈0.1）, C-peptide compared with the control group before treatment also increased（P〈0.5）,and the treatment group was significantly higher （P〈0.5）.Conclusion Skin liraglutide not only lower blood sugar, lose weight,low risk of hypoglycemia, to help maintain stable blood sugar, the most important is significantly regulate islet cell function, promote cell regeneration and differentiation of islet p, reducing the islet Day apoptosis, thereby increasing islet cells, increased C-peptide secretion.