乳腺癌患者既往恶心呕吐经历与化疗后恶心呕吐的关系探讨

Postchemotherapy nausea and vomiting and its relationship with previous experience of nausea and vomiting in patients with breast cancer

目的分析乳腺癌患者既往生活中恶心呕吐相关经历与化疗后恶心呕吐的关系。方法采用方便抽样法,以问卷调查117例乳腺癌术后患者化疗后恶心呕吐发生情况,以及既往生活中恶心呕吐相关经历,分析不同生活相关经历者化疗后恶心、呕吐发生率的差别。结果妊娠期有过恶心呕吐经历、容易晕车或晕船、晨起刷牙时易恶心、比他人更容易感到恶心的患者化疗后恶心、呕吐发生率显著高于无此类经历的患者(P<0.05,P<0.01)。结论既往容易发生恶心呕吐者更容易发生化疗后恶心、呕吐,需采取相应措施提前干预,以降低化疗后恶心呕吐发生率。

Objective To analyze the associations of postchemotherapy nausea and vomiting with previous experience of nausea and vomiting in patients with breast cancer.Methods A total of 117 patients with breast cancer were recruited by using a convenience sampling method and were investigated in terms of the incidence of postchemotherapy nausea and vomiting,and their previous experience of nausea and vomiting,to test the relationship between them.Results The incidences of postchemotherapy nausea and vomiting were significantly higher in patients who had experienced nausea and vomiting during pregnancy,who were more susceptible to motion sickness when traveling in cars or boats,who felt nausea when brushing teeth in the morning,or who were more likely to feel nausea than the others（P＜0.05,P＜0.01）.Conclusion Patients with a previous experience of nausea and vomiting are more susceptible to postchemotherapy nausea and vomiting,so targeted interventions should be taken in advance.