摘要
运用量子化学计算的方法 ,解析次黄嘌呤及其代谢的相关化合物,发现由次黄嘌呤代谢至尿酸的过程中,化合物自身能量逐步被提取,并且嘌呤母核化合物中先进行羟化的2位C-H键级较大。
Quantum chemistry calculation method was applied to description the characteristic of hypoxanthine and its metabolites. We found that the energy was extracted step by step in the metabolic process of hypoxanthine to uric acid, and the hydroxylation of the second position of purine in which the bond order is larger was taken place firstly.
出处
《海峡药学》
2013年第11期187-189,共3页
Strait Pharmaceutical Journal
关键词
量子化学
次黄嘌呤
代谢机制
Quantum chemistry
Hypoxanthne
Metabolic mechanism
