剖宫产术后抗菌药物预防产褥感染的用药方案研究

Study on the medication program of antibiotics preventing puerperal infection after cesarean section

目的探讨剖宫产术后抗菌药物预防产褥感染的更佳用药方案,为临床提供借鉴资料,减少产褥感染发生率。方法选择医院2011年12月-2012年5月进行剖宫产术的412例患者作为研究对象,按照不同用药方案分为A、B、C 3组,A组140例采用头孢硫脒治疗,B组124例采用头孢美唑治疗,C组148例采用头孢替唑治疗,比较3组用药方案的临床效果。结果 B组的产褥感染发生率为11.3%,明显高于A、C组的2.9%、4.1%,差异有统计学意义(P<0.05);但3组的术后发病率差异无统计学意义;C组的体温恢复时间明显短于A、B组,差异有统计学意义(P<0.05);3组的住院时间差异无统计学意义;3组的治疗费用排序为A组<C组<B组。结论临床工作者应根据剖宫产患者情况,选择经济、有效的抗菌药物预防术后产褥感染,保证患者生命安全。

OBJECTIVE To explore a better therapeutic regimen of antibiotics preventing puerperal infection after cesarean section, and to provide references for clinical information and reduce the rate of puerperal infection. METHODS From Dec. 2011 to May 2012, 412 cases of cesarean section patients in our hospital were selected as the subjects of study, and were divided into three groups in accordance with different therapeutic regimens, 140 cases in group A were treated with cefathiamidine, 124 cases in group B were treated with cefmetazole, 148 cases in group C were treated with ceftezole, then compared the clinical effect of the regimens in three groups. RESULTS The puerperal infection rate of group B was 11. 3%, which was significantly higher than group A （2.9 %） and group C （4.1 %）, the difference was statistically significant （P〈0.05） ; However, the difference of postoperative morbidity in the three groups had no statistical significance; the temperature recovery time of group C was significantly shorter than group A and B, and the difference was statistically significant （P〈0.05） ; the difference of hospitalization time in the three groups had no statistical significance; the sequence of treatment costs were group A〈group C〈group B. CONCLUSION Clinicians should select economic and effective postoperative antibiotics to prevent puerperal infection after cesarean section in accordance with the condition of patients, and to ensure the life safety of patients.