内科住院患者社区获得性肺炎的病原体分布及耐药性分析

Analysis on distribution and drug resistance of pathogens for patients with community-acquired pneumonia

目的分析内科住院患者社区获得性肺炎的病原体分布及耐药性,为临床合理用药提供依据。方法选择2006年6月-2011年11月在住院的457例社区获得性肺炎患者为研究对象,分析病原体分布及耐药性。结果在457例社区获得性肺炎患者的病原体检出中,检出86株肺炎链球菌,检出率为18.8%,明显高于其他病原菌;71株肺炎链球菌对红霉素,耐药率为82.6%,28株嗜血菌属对环丙沙星,耐药率为77.8%,均明显高于对其他抗菌药物的耐药性,差异有统计学意义(P<0.05)。结论在社区获得性肺炎中,肺炎链球菌是主要的病原菌;在非典型病原体中,肺炎支原体是主要的病原体。

OBJECTIVE To analyze the distribution and drug resistance of pathogens in medical hospitalized patients with community-acquired pneumonia, and provide the basis for rational clinical drug utilization. METHODS From Jun. 2006 to Nov. 2011,457 patients with community-acquired pneumonia were selected as objects in our hospi-tal, in which the distribution and drug resistance of pathogens were analyzed. RESULTS In 457 cases of patients with community-acquired pneumonia, 86 strains of Streptococcus pneurnoniae were detected and the detection rate was 18.8%, which was significantly higher than other pathogens; 71 strains of S. pneumoniae were resistant to erythromycin, and the drug resistance rate was 82.6 %, which was significantly higher than the resistance rate o~ other antibiotics; 28 strains of Haemophilus were resistance to ciprofloxacin, and the drug resistance rate was 77.8%, which was also significantly higher than the other antibiotics. The differences were statistically significant （P〈0. 05）. CONCLUSION In the patients with community-acquired pneumonia, S. pneumoniae is the major pathogen; in the atypical pathogens, Mycoplasma pneumomiae is the major pathogen.