期刊文献+

主动外排系统介导阴沟肠杆菌耐药机制新进展 被引量:5

原文传递
导出
摘要 阴沟肠杆菌(ECL)是存在于人和动物肠道内的正常菌群,由阴沟肠杆菌导致的感染多与严重的基础疾病,以及长期应用广谱抗菌药物和免疫抑制剂等因素有关,已成为院内获得性感染越来越重要的病原菌。近年来,由于长期和不合理使用广谱抗菌药物,使细菌产生多药耐药性(MDR)成为全球医疗难题。
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2013年第23期5894-5896,共3页 Chinese Journal of Nosocomiology
基金 北京市中医药管理局中西医结合感染性疾病重点学科基金项目(京中医科字[2012]250)
  • 相关文献

参考文献22

  • 1Falagas ME, Karageorgopoulos DE. Pandrug Resistance (PDR) , extensive drug resistence (MDR) among gram-negative bacilli: Need for international harmonization in terminology[J]. Clin In?fect Dis,2008,46(7) :1121-1122.
  • 2李博,马忠森,徐雪松.常见肠杆菌属细菌的耐药性研究[J].中国实用医药,2011,6(32):182-183. 被引量:5
  • 3Poole K. Effux pumps as antimicrobial resistance mechanisms[n Ann Med,2007,39(3):162-176.
  • 4Perez A, Poza M, Fernandez Ana, et al , Involvement of the AcrAB-ToIC Efflux Pump in the Resistance, Fitness, and Virulence of Enterobacter cloacae[J]' Antimicrob Agents Chemother , 2012,56 (4) : 2084-2090.
  • 5胡小行,李国明,刘军,石正琪.外排泵抑制剂对阴沟肠杆菌耐药表型影响[J].中国微生态学杂志,2011,23(3):243-245. 被引量:3
  • 6Daurel C, Fiant AL, Brernont S, et al . Emergence of an Enter?obacter hormaechei Strain with Reduced Susceptibility to Tigecycline under Tigecycline Therapy[J]. Antimicrob A?gents Chernother , 2009,53(11) : 4953-4954.
  • 7Hornsey M, Ellington MJ, Doumith M, et al . Emergence of AcrAB-mediated tigecycline resistance in a clinical isolate of Enterobacter cloacae during ciprofloxacin treatment[J]. IntJ Antimicrob Agents,2010,35(5) :478-481.
  • 8Tikhonova EB, Yamada v . Zgurskaya H. Sequential Mecha?nism of Assembly of Multidrug Efflux Pump AcrAB- TolC[n. Chemistry s, Biology, 2011,18: 454-463.
  • 9侯进慧,陈宏伟,高兆建,蔡侃.肠杆菌科AcrAB多药外排泵分子演化分析[J].生物技术,2010,20(4):18-21. 被引量:1
  • 10Nakashima R,Sakurai K, Yamasaki Svez al. Structures of the multidrug exporter AcrB reveal a proximal multisite drug?binding pocket[J]. Nature,2011,480:565-569.

二级参考文献20

  • 1SHIWei-feng,JIANGJian-ping,XUNing,HUANGZhi-mi,WANGYu-yue.Inhibitory effects of reserpine and carbonyl cyanide m-chloro-phenylhydrazone on fluoroquinolone resistance of Acinetobacter baumannii[J].Chinese Medical Journal,2005(4):340-343. 被引量:5
  • 2王青松,崔淑芹,张舒.细菌外排泵介导耐药性研究进展[J].国外医药(抗生素分册),2005,26(3):97-100. 被引量:18
  • 3Francoise V B, Elisabetta B, Paul M T. Antibiotic Efflux Pumps[J]. Biochem Pharmacol, 2000,60(4) : 457 -470.
  • 4Nikaido H. Muhidrug Eftlux Pumps of Gram - Negative Bacteria[ J ]. J Bacterioi, 1996,178 (20) : 5853 - 5859.
  • 5Yu E W, Aires J R, Nikaido H. AcrB muhidrug efflux pump of Escherichia coli : A composite substrate - binding cavity of exceptional flexibility generates its extremely wide substrate specificity[ J]. J Bacteriol, 2003, 185 (18) : 5657 -5664.
  • 6Yu E W, McDermott G, Zgruskaya H I. Structural basis of multiple drug binding capacity of the AcrB multidrug efflux pump [ J ]. Science, 2003, 300 : 976 - 980.
  • 7Murakami S. , Nakashima R. , Yamashita E. Crystal structure of bacterial muhidrug efflux transporter AcrB [ J ]. Nature, 2002, 419 ( 6907 ) :587 - 593.
  • 8Nikaido H. AcrA is a highly asymmetric protein capable of spanning the periplasm[ J]. J Mol Biol, 1999, 285 (1) : 409 -420.
  • 9Elkins C A, Nikaido H. Chimeric analysis of AcrA function reveals the importance of its C - Terminal domain in its interaction with the AcrB multidrug efflux pump [ J ]. J Bacteriol, 2003,185 ( 18 ) : 5349 - 5356.
  • 10Husain F, Humbard M, Misra R. Interaction between the TolC and AcrA proteins of a multidrug efflux system of Escherichia coli[ J ]. J Bacteriol, 2004,186 (2) : 8533 -8536.

共引文献6

同被引文献41

  • 1Kaneko K,Okamoto R,Nakano R,et al.Gene mutations responsible for overexpression of AmpC beta-lactamase in some clinical isolates of Enterobacter cloacae[J].J Clin Microbiol,2005,43(6):2955-2958.
  • 2Mezzatesta ML, Gona F, Stefani S. Enterobacter cloacae complex: clinical impact and emerging antibiotic resistance [ J ]. Future Mi- crobiol, 2012,7(7) :887-902.
  • 3Zheng J, Cui S, Meng J. Effect of transcriptional activators RamA and SoxS on expression of multidrug efflux pumps AcrAB and AcrEF in fluoroquinolone- resistant Salmonella Typhimurium[ J]. J Antimicrob Chemother, 2009,63 ( 1 ) :95-102.
  • 4Keeney D, Ruzin A, Bradford PA. RamA, a transcriptional regu- lator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae [ J ]. Micreb Drug Resist, 2007,13 ( 1 ) : 1-6.
  • 5Bratu S, Landman D, George A, et al. Correlation of the expres- sion of acrB and the regulatory genes marA, soxS and 'ramA with an- timicrebial resistance in clinical isolates of Klebsiella pneumoniae endemic to New York City[J]. J Antimicmb Chemother, 2009,64 (2) :278-283.
  • 6Perez A, Canle D, Latasa C, et al. Cloning, nucleotide sequen- cing, and analysis of the acrAB-TolC efilux pump of Enterobacfer cloacae and determination of its involvement in antibiotic resistance in a clinical isolate[ J]. Antimicrob Agents Chemother, 2007,51 (9) :3247-3253.
  • 7Astfid Prez, Margarita Poza, Ana Fem0ndez, et al. Involvement of the AcrAB-TolC efflux pump in the resistance, fitness, and viru- lence of enterobacter cloacae [ J ]. Antimicrob Agents Chemother, 2012,56(4) :2084-2090.
  • 8Yang FC, Yan JJ, Hung KH, et al. Characterization of ertapenem- resistant enterobacter cloacae in a Taiwan Residents university hospital [J]. J Clin Microbiol, 2012,50(2) :223-226.
  • 9Paterson DL, Bonomo RA. Extended-spectrum beta-lactamases: a cllnicalupdate [ J ]. Clin Microbiol Rev, 2005,18 (4) :657 -686.
  • 10谭友坤.678株革兰阴性杆菌的耐药监测分析[J].实用预防医学,2010,17(9):1873-1875. 被引量:1

引证文献5

二级引证文献35

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部