CEA、CA125、CYFRA21-1、NSE联合检测肺癌的临床价值

Significance of combined detection of CEA,CA125,CYFRA21-1 and NSE for lung cancer

目的:探讨血清肿瘤标志物癌胚抗原(CEA)、糖类抗原125(CA125)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)联合检测对肺癌诊断的临床价值。方法:采用放射免疫法检测112例肺癌患者、38例肺良性疾病患者及36例正常人血清中CEA、CA125、CYFRA21-1、NSE的表达。结果:4项肿瘤标志物在单项检测时,肺癌患者的血清表达水平均显著高于肺良性疾病患者和正常人(均P<0.01);联合检测的灵敏度(83.93%)、准确度(87.63%)均优于单项检测,差异有统计学意义(均P<0.05)。结论:4项标志物对肺癌的辅助诊断均有实用价值,且联合检测有助于提高肺癌诊断的灵敏度和准确度。

Objective： To investigate the clinical value of the combined detection of carcinoembryonic antigen（ CEA）,carbohydrate antigen 125（ CA125）,cytokeratin 19 fragment（ CYFRA21-1）,neuron specific enolase（ NSE） in the diagnosis of lung cancer. Methods： The serum levels of CEA,CA125,CYFRA21-1 and NSE were determined by Radioimmunoassay in 112 patients with lung cancer and 38 patients with benign pulmonary disease and 36 health adults. Results： The serum levels of four tumor markers were significantly higher in patients with lung cancer than those with benign pulmonary disease and / or health adults（ all P 0. 01）. The combined detection of four tumor markers demonstrated higher sensitivity（ 83. 93%） and accuracy（ 87. 63%） in the lung caner compared with any single tumor marker detection（ all P 0. 05）. Conclusion： There is certain diagnostic value of CEA、CA125、CYFRA21-1 and NSE in lung cancer,and complementarity of combined detection of the four markers,which could significantly improve sensitivity and accuracy in the diagnosis of lung cancer.