8-芳基-2-吡啶甲酰-1-萘胺的合成与表征

Synthesis and characterization of N-( 8-arylnaphthalen-1-yl)picolinamide

以1-萘胺为原料,与2-吡啶甲酸通过脱水缩合生成2-吡啶甲酰-1-萘胺反应底物。随后,在导向基团2-吡啶甲酰胺的螯合作用下,钯催化活化2-吡啶甲酰-1-萘胺的8-C—H键与芳基碘化物直接反应,一步及高区域选择性地合成标题化合物。产物结构均通过1HNMR、13CNMR和ESI-HRMS确证。

A series of N-（ 8-arylnaphthalen-l-yl ）-picolinamides were synthesized via the first step of condensation reaction of naphthalen-l-amine with picolinic acid and the second step of palladium （Ⅱ）-catalyzed regioselective 8-C--H bond of N-（naphthalen-l-yl）picolinamide arylation reaction with aryl iodides. The structures of the compounds were confirmed by ^1 HNMR,^13CNMR,ESI-HRMS.