植入式压力反射刺激装置治疗顽固性高血压的研究进展

Advances of Implanted Baroreflex Stimulation for Treatment of Resistant Hypertension

高血压患者使用了3种或3种以上的降压药物包括利尿剂在内而难以使血压得到有效的控制,称为顽固性高血压。血压的调节涉及多种因素,主要为内皮功能、自主神经、肾素-血管紧张素系统三种调节系统。药物虽能作用于各调节系统,但对于顽固性高血压患者疗效却有限,近年来有两种新技术用于抗交感神经治疗顽固性高血压,即肾动脉交感神经射频消融术和植入式压力反射刺激装置,现就后者作一综述。

Resistant hypertension is defined as blood pressure that is beyond control in spite of using three antihypertensive agents of different classes including diuretics. Blood pressure regulation involves multiple factors, 3 main important factors of which are autonomic nervous system, endothelial system and renin-angiotensin-aldosterone system. Though drugs may block regulation systems, its effects in resist- ant arterial hypertension are limited. Recently, two new techniques, radiofrequency ablation of renal artery sympathetic and implanted baroreflex stimulation, are applied to the treatment of resistant arterial hypertension through antisympathetic. We will review the latter device in this article.