摘要
心脏钙离子释放通道之一阿诺碱2型受体的研究在近20年已获得巨大的进展。现简要地复习它的功能、调节,它与某些心血管病如心律失常(儿茶酚胺敏感的多形性室性心动过速、致心律失常性右心室心肌病和心房颤动)、心力衰竭、心肌梗死和药源性高血压的关系以及阻滞阿诺碱受体通道药物包括苯并硫氮衍化物和苯二酚。现对心肌梗死分类为心肌钙通道病范畴的见解提出疑问。
Research of cardiac calcium ion release channel（RyR2） had obtained great advance in recent 20 years. Function,regula- tion of RyR2 and its relationship with some cardiovascular diseases such as arrhythmia （catecholaminergic polymorphic ventricular tachycardi- a,arrhythmogenic right ventricular cardiomyopathy and atrial fibrillation） ,heart failure,myocardial infarction and drug-induced hypertension and drugs which block RyR2 channel such as JTVS19 and S107 are reviewed in brief in this paper. We question this view that myocardial in- farction should be classificated as category of cardiac calcium ion channelopathy.
出处
《心血管病学进展》
CAS
2013年第6期806-811,共6页
Advances in Cardiovascular Diseases
关键词
心脏钙离子释放通道
心律失常
心力衰竭
心肌梗死
药源性高血压
cardiac calcium ion release channel
arrhythmia
heart failure
myocardial infarction
drug-induced hypertension
