基质金属蛋白酶及其抑制剂与高血压病的研究进展

Research Progress of Matrix Metalloproteinases and Their Inhibitors in Hypertension

基质金属蛋白酶是一族Zn2+依赖的蛋白水解酶,主要负责组织重塑与细胞外基质的降解,能够降解细胞外基质,在胚胎的发育、组织重构、炎症调控、肿瘤疾病等多种生理过程中起重要作用。现就其在高血压病的发生、发展及靶器官功能损害中的作用机制、临床意义及其治疗新进展阐述如下。

Matrix metalloproteinases are a family of Zn2 ＋ dependent protein hydrolysis enzyme, are mainly responsible for the degra- dation of extracellular matrix and tissue remodeling, can degrade extracellular matrix, and play an important role in various physiological processes such as embryonic development, tissue remodeling, inflammation control, tumor disease, and so on. Now the mechanism of action in the occurrence and development of hypertension and target organ damage, clinical significance and treatment progress is elaborated in this paper.