川崎病患儿血清TNF-α、IL-6变化及其与冠状动脉病变之间关系的探讨

Relational exploration for the change of serum TNF-α and IL-6 with coronary artery disease in children with Kawasaki disease

为探讨肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)在川崎病(KD)发病中的作用以及其与KD冠状动脉病变(CAD)之间的关系,采用ELISA测定KD患儿血清TNF-α和IL-6水平,与正常对照组进行比较,并将KD并CAD组与无CAD组进行比较。结果KD患儿血清TNF-α和IL-6皆明显高于正常对照组(P<0.01),TNF-α在KD并CAD组患儿亦高于无CAD组患儿(P<0.05),而IL-6在两组中无显著差别(P>0.05)。提示TNF-α和IL-6皆参与了KD的发生,而TNF-α在KD患儿CAD中,可能起到比IL-6更为重要的作用。

To explore the role of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in the pathogenesis of Kawasaki disease (KD), and the relationship for the change of serum TNF-α and IL-6 with coronary artery disease (CAD) in KD children, serum TNF-α and IL-6 were detected by ELISA in 26 KD patients, in whom there were 9 cases with complicated CAD, and 25 normal children, respectively. It was found that the levels of serum TNF-α and IL-6 were significantly higher in the KD group than that in the normal group (t' = 8. 63,P<0. 01). The level of serum TNF-α increased obviously in the KD group with CAD comparing to KD children without CAD (t= 2. 047,P<0. 05) while IL-6 did not. It is suggested that both TNF-α and IL-6 are all involved in the pathogenesis of KD, in particular TNF-α may play an important role in the KD patients with complicated CAD.