庆大霉素联合肝素钠封管在预防中心静脉导管感染中的临床研究

Sealing Tubes with Gentamicin and Heparin Sodium for Prevention of Central Venous Catheter Infection

目的探讨庆大霉素联合肝素封管在预防中心静脉导管感染中的应用。方法选取经中心静脉导管进行血液净化的100例患者为研究对象,按封管方法的不同分为研究组与对照组,每组50例。对照组采用常规肝素钠2.5mL封管,研究组采用庆大霉素0.25mL联合肝素钠2.25mL封管。随访3个月,比较2组导管感染率及封管后感染发生的时间。结果研究组导管感染率为4%(2/50),低于对照组的18%(9/50)(P<0.05);研究组封管后感染发生的时间为(32.1±3.1)d,晚于对照组的(30.8±2.5)d(P<0.05)。结论使用庆大霉素联合肝素钠封管能降低导管感染率,且能推迟导管感染的时间。

Objective To investigate the application of sealing tubes with gentamicin and heparin sodium in the prevention of central venous catheter infection. Methods One hundred patients undergoing hemodialysis through temporary central venous catheters were randomly divided into two groups,with 50 patients in each group. Thbes were sealed with heparin sodium （2.5 mL） in control group and combined gentamicin （0. 25 mL） and heparin sodium （2.25 mL） in experimental group. After 3 months of follow-up,catheter infection rate and infection time were compared between the two groups. Results Catheter infection rate in experimental group （4%, 2/50） was significantly lower than that in control group （18%,9/50）（P〈0.05）. In addition, infection time in experimental group [（32.1±3.1）days] was later than that in control group[（30. 8±2.5） days]（P〈0. 05）. Conclusion Sealing tubes with gentamicin and heparin sodium can reduce catheter infection rate and delay catheter infection time.