鼻咽癌复发与残存病变分次立体定向放射治疗

Fractionated stereotatic radiotherapy for 50 patients with recurrent and residual nasopharyngeal carcinoma

目的 初步评价分次立体定向放射治疗技术用于鼻咽癌放射治疗后残存病变或复发的推量治疗的临床价值。方法 5 0例鼻咽癌放射治疗后残存病变或复发的患者 ,应用科瑞特公司生产的立体定向放射治疗系统。 6MVX射线总剂量DT2 4～ 30Gy ,1～ 4个中心 ,参考剂量曲线选定为 6 0 %～ 90 %。分割方式 :6～ 8、12、15Gy/次 ,间隔 4～ 6d。结果 肿瘤完全消失占 76 % (38/ 5 0 ) ,部分消退占18% (9/ 5 0 ) ,不能评价占 6 % (3/ 5 0 )。 1、2、3年生存率分别为 83.6 %、6 5 .0 %、5 9.6 %。

Objective To evaluate the value of fractionated stereotatic radiation therapy (FSRT)(X knife) as a boost for recurrent or residual nasopharyngeal carcinoma (NPC) at the primary focus. Methods From Sept.20, 1995 to Dec.30,1998, 50 such patients were treated by FSRT with 6 MV photons. The total FSRT dose was 24～30?Gy prescribed at 1～4 centers on the 60%～90% isodose curves normalized to isocenter by multifractions of fraction size 6～8?Gy, 12,15?Gy, with interfraction duration of 4～6 days. Results CR 38/50 (76%), PR 9/50 (18%) and in evaluated 3/50 (6%). Total survivals(Kaplan meier):1 yr 83.6%, 2 yr 65.0% and 3 yr 59.6% . Conclusion Fractionated stereotatic radiotherapy (FSRT) is strongly indicated for recurrent or residual NPC at the primary focus.