5例肝局灶性结节性增生的临床病理学观察

Hepatic focal nodular hyperplasia: A clinicopathological analysis of 5 cases

目的 观察肝局灶性结节性增生 (FNH)的病理特点。方法 采用HE和免疫组化技术对 5例FNH进行病理学观察。结果 5例FNH临床均误诊为肝癌。术后随访 4例 ,4月～ 11年 ,健在。FNH病理学特征为孤立的、有纤维疤痕的结节性肿块。纤维疤痕中可见厚壁血管。CD34在肝血窦内皮细胞呈阳性。讨论 纤维疤痕是FNH的形态特征。应与肝细胞癌 ,纤维板层状肝癌及肝腺瘤鉴别。

Objective To observe the pathological changes of the hepatic focal nodular hyperplasia (FNH). Methods Five cases of FNH in the liver were studied with HE staining and immunohistochemistry. Results All the cases were misdiagnosed as hepatic cell carcinoma (HCC) initially , with follow-up for 4 months to 11 year in 4 cases. The pathological features were a solitary and nodular mass with fibrous scar that contained thick-walled vessels and CD34 positive in the endothelial cells. Conclusions The scar is one of the features of hepatic FNH, which should be differentiated from HCC, fibrous lamella carcinoma and hepatic adenoma. Disturbances of circulation of blood may be the cause of FNH in the liver.