铜绿假单胞菌下呼吸道感染的临床分析

Analysis of Clinical Characteristics and Drug sensitivity Tests of Lower Respiratory Tract Infection by Pseudomonas Aeruginosa

目的 :分析和总结铜绿假单胞菌下呼吸道感染的临床特点及抗生素敏感性的分布情况。方法 :对 2 8例铜绿假单胞菌下呼吸道感染的临床资料进行综合分析 ,采用纸片法 (Kirby- Bauer)测定该菌的体外药物敏感性。结果 :2 8例患者均有基础肺部疾病 ,其中以慢性支气管炎最常见。临床上表现为发热、咳嗽、咳痰 ,脑部 X线表现为双肺淡薄、斑片状阻影。药敏试验表明 ,铜绿假单胞菌对头孢他啶、头孢哌酮耐药率增加。结论 :铜绿假单胞菌下呼吸道感染多发生在患有各种基础疾病 ,尤其是肺部疾病患者 ,临床表现无特异性 ,耐药率有增加趋势。

Objective: To analyse the clinical characteristics of lower respiratory tract infection caused by pseudomonas aeruginosa(PA) and to investigate the antibiotic sensitivity of PA strains. Method: Retrospective study of the clinical data of 28 cases with lower respiratory tract infection by PA was conducted. Drug sensitivity to strains of PA by K-B method was studied. Result: All of 28 cases had diseases in pulmones, most of which were chronic bronchitis. Clinical manifestations include fever、 cough and expectoration. The chest X-ray revealed infiltration in lobes of both lungs. The drug sensitivity test showed that antibiotic resistance of PA for ceftazidime and cefoperazone was increasing. Conclusion: The lower respiratory tract infections caused by PA develop in patients with various primary diseases, especially in the patients with pulmonary diseases. The clinical characteristic of lower respiratory tract infection by PA was not specific. There has been a steady increase of antibiotic resistance during these years.