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利巴韦林鼻腔喷雾剂的制备及稳定性观察

The preparation of Ribavirin nasal spray and its stability
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摘要 本文所述制剂为鼻腔喷雾剂的一种,其采用新型高分子材料卡波普(Carbopol)及对鼻纤毛毒性较小的苯扎溴胺作为制剂的辅料;在碱性条件下(pH11.0),利用一阶导数分光光度法消除辅料的干扰,在227±1nm处直接测定利巴韦林的含量,平均回收率为100.017% ,RSD=0.35% ;以经典恒温法进行稳定性观察.在常温下,保存期为2年以上. This preparation adopts Carbopol as thickening agent and benzalkonium bromide as preserving agent. With the firstorder derivative ultraviolet spectrophotometry as the analytic method to avoid the influence of accessory material (pH = 11. 0, λmax=226. 0 ± 1nm), the content of Ribavirin can be determined directly. The mean rate of recovery is 100. 17%, and the RSD is 0. 35% , This method is simple, accurate and suitable for routine analysis, We also estimate the stability of this preparation with classical constant temperature test, The result is that this preparation can be preserved for two years under normal temperature.
出处 《儿科药学》 1999年第4期13-14,48,共3页 Journal of Pediatric Pharmacy
关键词 利巴韦林 鼻腔喷雾剂 一阶导数分光光度法 稳定 Ribavirin, Carbopol, nasal spray, stability, firstorder derivative ultraviolet spectrophotometry.
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