脂质体阿霉素与阿霉素对小鼠毒性作用的比较研究

The comparative study of toxicity of liposome adriamycin and adriamycin for mice

目的 对比研究阿霉素和脂质体阿霉素对小鼠的毒性作用。方法 将脂质体阿霉素与阿霉素分为几个不同的剂量组 ,观察静脉给药后两种剂型的急性LD50 、小鼠血白细胞计数和血液生化变化及两药物组动物心、肝、肾、胃肠道等脏器的病理及心肌超微结构变化。结果 脂质体载药可将药物LD50 提高 6 0 % ,动物毒性死亡率降低 ,动物血白细胞和血液生化改变明显减轻。病理检查提示 :脂质体组动物心、肾、胃肠道病理损害减轻 ,而肝、脾病理改变两药物组相仿。结论 脂质体载药后可降低阿霉素对动物心、肾。

Objective To study the toxicity of Free-adriamycin(F-ADM) and Liposome-adriamycin(L-ADM) for mice by contrast. Methods Giving several corresponding doses of L-ADM and F-ADM in vein; Then detecting LD 50 of the two drugs; Observing blood biochemical changes of the mice and the pathological changes of heart,liver,kidney and gastroenteron.Results The LD 50 of F-ADM was increased 0.6 times after liposome entrapped drug.Compared to F-ADM,L-ADM effectively reduced the changes of blood biochemical and pathological damage as cardiotoxicity, nephrotoxicity and gastroenterotoxicity while the changes in liver and spleen remained the same in both.Conclusion Liposome agent significantly diminished the toxicity of adriamycin in the important organs of the body.