308nm准分子光联合0.03%他克莫司软膏治疗面部白癜风疗效观察

Efficacy of 308 nm excimer light combined with tacrolimus ointment 0.03% in the treatment of facial vitiligo

目的探讨308 nm准分子光联合0.03%他克莫司软膏治疗面部白癜风疗效及安全性。方法选取面部白癜风患者129例,按就诊顺序分为3组,A组为试验组,43例患者采用308 nm准分子光联合0.03%他克莫司软膏治疗;B组为对照1组,43例患者单用308 nm准分子光治疗;C组为对照2组,43例患者单用0.03%他克莫司软膏外用治疗,疗程均为12周或治疗至皮损完全复色。结果 A组、B组、C组的显效率分别为73.80%、47.61%、17.07%,A组与B组和C组显效率比较,差异有统计学意义(P<0.05)。3组患者均未出现严重不良反应。结论 308 nm准分子光联合0.03%他克莫司软膏治疗面部白癜风疗效好、不良反应少,显效率明显高于单独治疗。

Objective To evaluate the efifcacy and safety of 308 nm excimer light combined with tacrolimus ointment 0.03%for facial vitiligo. Methods A total of 129 outpatients with facial vitiligo were randomly divided into three groups, each group included 43 cases. Group A as the treatment group, treated with 308 nm excimer light combined with tacrolimus ointment 0.03%;Group B and C as controls were respectively treated with 308 nm excimer light or tacrolimus ointment 0.03%. The study lasted for 12 weeks or finished until complete repigmentation of the lesions. Results The signiifcant efifciency of the group A, B and C was 73.80%, 47.61%and 17.07%respectively, there was signiifcant difference between the group A and the other two groups （P〈0.05）. There was no serious adverse reaction occurred in all the patients. Conclusion For the treatment of facial vitiligo, the efifciency of 308 nm excimer light combined with tacrolimus ointment 0.03%is signiifcant higher than the monotherapy, meanwhile with fewer adverse reactions.