硅胶支载稀土氯化钐一步催化合成多取代Mannich碱

Synthesis of Multiaryl-substituted Mannich Base Catalysed by Silica-supported Rare Earth Samarium Chloride

采用硅胶与稀土氯化钐在甲苯或四氯化碳中反应,制备了硅胶支载稀土氯化钐.与已报道的支载型催化剂相比,所制备的硅胶支载稀土氯化钐作为催化剂具有支载量稳定、催化反应时间短、产率高和选择性强等优点,同时催化反应条件温和、操作简便、不污染环境且催化剂重复利用率高.室温条件下,以硅胶支载稀土氯化钐作为催化剂催化对甲氧基苯乙酮、芳香醛和芳香胺的三组分体系,利用'一锅法'合成了28种新的β-氨基酮类化合物,并探索了不同反应条件对产率的影响.催化剂经过IR和XRD表征,催化反应产物通过IR、1H NMR和元素分析确定.

Many supported-catalysts are applied to the Mannich reaction, but they have disadvantages of low yield, unstability of supported rate and asking for long time. Silica-supported rare earth samarium chloride （SiO2-OSmC12 ） was prepared by the reaction of silica and rare earth samarium chloride in toluene or CCIa. The effects of different reaction conditions on the yields were investigated. This protocol has advantages of sta- bility of supported rate, short time, mild condition, high yield, high selectivity, simple work-up, environmen- tal friendly procedure and the catalyst can be reused. The three components of p-methoxyacetophenone, aro- matic aldehydes and aromatic amines were reacted by one-pot Mannich reaction and catalysed by SiO2-OSmC12 in ethanol at room temperature. As results, a series of new fl-Amino carbonyl compounds were synthesized. The catalyst was characterized via IR and XRD, simultaneously the products were determined by IR, ~H NMR and elemental analysis.