胺碘酮用于房颤复律及维持窦律的随访观察

Effect of amiodarone on cardioverison and maintaining sinus rhythm in atrial fibrillation patients

目的 :观察胺碘酮用于房颤复律及转复后维持窦律的长期疗效和安全性。方法 :对病程 18m o内的 32例房颤患者用胺碘酮片 6 0 0 m g/ d,用药的前 3d加用 40 0～ 6 0 0 mg/ d胺碘酮注射液 iv gtt,复律后维持低剂量 (2 0 0 m g/ d)的胺碘酮治疗且随访 3a。结果 :有 30例患者复律成功。维持窦律的有效率 :6 mo为 6 9.7% ,12 m o为 93.3% ,2 4m o为 86 .7% ,36 m o为 73.3%。结论 :胺碘酮是房颤转复及维持窦律的有效药物。

AIM: To study the effect of amiodarone on cardioverison and maintaining sinus rhythm in atrial fibrillation. METHODS: Thirty two patients with atrial fibrillation using amiodarone 400-600 mg/d by intravenous infusion for 3 d and 600 mg/d by oral administration for 1 wk, then oral for maintaining dose (200 mg/d) following up for 36 mo. RESULTS: 6 mo, 12 mo, 24 mo and 36 mo after amiodarone treatment. The clinical effective rate was 96 7%, 93 3%, 86 7% and 73 3% respectively. CONCLUSION: Amiodarone may provide an effective therapeutic approach to cardioverison and maintaining sinus rhythm in patients with atrial fibrillayion.