4-苯并呋喃乙酸的合成

Synthesis of 4-Benzofuranacetic Acid

间苯二酚常压催化氢化得到 1,3-环己二酮 ,经缩合、Reformatsky反应、脱氢反应 ,得到 4-苯并呋喃乙酸乙酯 ,再水解酸化后 ,得到依那朵林合成中的关键中间体 4-苯并呋喃乙酸。

Resorcinol was subjected to normal pressure hydrogenation in the presence of Raney Ni to give 1,3-cyclohexadione which was followed by condensation, Reformatsky reaction, dehydrogenation, saponification and acidification to afford 4-benzofuranacetic acid, which is the key intermediate of kappa opioid agonist——enadoline.