美托洛尔联合硝苯地平对76例高血压患者的治疗体会

Treatment experience of metoprolol combined with nifedipine in the treatment of patients with hypertension in 76 cases

目的探讨美托洛尔联合硝苯地平在治疗原发性高血压中的应用价值。方法 76例原发性高血压患者,根据不同治疗方式分为对照组38例(口服硝苯地平缓释片)和试验组38例(美托洛尔+硝苯地平联合治疗),治疗3个月后比较2组疗效。结果试验组治疗总有效率为92.1%明显高于对照组的73.7%,差异有统计学意义(P<0.05);试验组患者血压下降幅度较对照组更明显,差异有统计学意义(P<0.05);试验组药物不良反应发生率为7.9%低于对照组的28.9%,差异有统计学意义(P<0.05)。结论美托洛尔联合硝苯地平治疗原发性高血压具有安全性高、降压效果显著,值得临床推广应用。

Objective To investigate the value of clinical application of metoprolol combined with nifedipine in the treatment of essential hypertension. Methods 76 cases of patients with essential hypertension were divided into the control group （extended release nifedipine tablets alone） and the experimental group （metoprolo] and nifedipine combined treat- ment） ,each of 38 cases. After treatment for 3 months,the therapeutic effect of the 2 groups were observed and compared. Re- suits The total effective rate of the experimental group was 92.1%, which was higher than 73.7 % of the control group, and the difference was statistically significant （P 〈 0.05 ）. The blood pressure descend range of the experimental group was more obviously than that of the control group, and the difference was statistically significant （P 〈 0.05）. The incidence of adverse re- action of the experimental group was 7.9% ,which was lower than 28.9% of the control group,and the difference was statisti- cally significant （P 〈 0.05）. Conclusions Metoprolol and nifedipine combined treatment has high safety and obvious antihy- pertensive effect in the treatment of essential hypertension, which is worthy of clinical application.