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利妥昔单抗治疗难治性IgA肾病Ⅱ期1例 被引量：8

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摘要 患者,女性,21岁,4年前患上呼吸道感染后出现双下肢水肿及肉眼血尿,就诊于长治市人民医院,查Bp 110/80mm Hg,尿蛋白（＋＋）、潜血（＋＋＋）,24h尿蛋白2.06g,血总蛋白47.3g/L,清蛋白29.4g/L,总胆固醇5.30mmol/L,甘油三酯2.6mmol/L,血肌酐149μmol/L,尿酸416μmol/L.肾活检病理回报：光镜下见36个肾小球,4个小球近于球性硬化,肾小球细胞数不增多,系膜细胞节段性增生,系膜基质局灶节段性增多伴硬化,毛细血管开放,可见较多微血栓,
作者 马凤申 王金立 马建松 王培顺
机构地区 石家庄市肾病医院
出处 《临床合理用药杂志》 2013年第32期141-142,共2页 Chinese Journal of Clinical Rational Drug Use
关键词 IGA肾病 利妥昔单抗 治疗机制
分类号 R692.3 [医药卫生—泌尿科学]
  • 相关文献

参考文献4

  • 1Pozzi C, Andml]i S, Pani A, et al. Addition of azathioprine to corficoste- voids does not benefit patients with IgA nephropathy [ J ] Am Sot: Nephrology,2010,21 (10) : 1783 - 1790.
  • 2朱碧溱,黄建萍.利妥昔单抗治疗难治性肾病研究进展[J].中华儿科杂志,2009,47(11):845-847. 被引量：6
  • 3Haas M. Histologic subclaification of lgA nephropathy: a clinicepatho- logic study of 244 cases. [J]. Am J Kidney Dis,1997,29 (6) :829 - 842.
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二级参考文献25

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共引文献5

同被引文献146

  • 1缪怡,胡朝英,钱柳,张冬青.类风湿性关节炎免疫学研究进展[J].上海交通大学学报（医学版）,2011,31(7):1035-1040. 被引量：37
  • 2贺理宇,刘虹,彭佑铭.IgA肾病免疫机制与治疗靶点研究进展[J].中南大学学报（医学版）,2014,39(1):96-101. 被引量：17
  • 3吗替麦考酚酯在肾内科应用专家协作组.吗替麦考酚酯在肾内科应用的指导意见[J].中华肾脏病杂志,2004,20(5):385-385. 被引量：18
  • 4方玲,吴志英,王柠,林珉婷,慕容慎行.结节性硬化症TSC1基因编码外显子全长的突变检测与分析[J].中华神经科杂志,2005,38(2):108-111. 被引量：12
  • 5张馨,鲍浩,唐政,俞雨生,王金泉,刘志红,黎磊石.三联疗法治疗IgA肾病尿检异常型疗效分析[J].肾脏病与透析肾移植杂志,2007,16(3):209-214. 被引量：18
  • 6KDIGO. Chapter 10 : Immunoglobulin A nephropathy [ J ]. Kidney Int Suppl(2011), 2012, 2(2) : 209 -217.
  • 7Coppo R, Peruzzi L, Amore A, et al. IgACE : a placebo-controlled, randomized trial of anglotensin-eonverting enzyme inhibitors in children and young people with IgA nephropathy and moderate proteinuria[J]. J Am Soc Nephrol, 2007, 18(6): 1880-1888.
  • 8Pozzi C, Andrulli S, Pani A, et al. Addition of azathioprlne to corti- costeroids does not benefit patients with IgA nephropathy[J]. J Am Soc Nephrol, 2010, 21 (10) : 1783 - 1790.
  • 9Maes BD, Oyen R, Claes K, et al. Mycophenolate mofetil in IgA nephropathy: results of a 3-year prospective placebo-controlled randomized study [J]. Kidney Int, 2004, 65 (5) : 1842 - 1849.
  • 10Frisch G, Lin J, Rosenstock J, et al. Myeophenolate mofetil (MMF) vs placebo in patients with moderately advanced IgA nephropathy: a double-blind randomized controlled trial[J]. Nephrol Dial Transplant, 2005, 20(10): 2139-2145.

引证文献8

二级引证文献33

临床合理用药杂志
2013年 第32期

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